Vaccination Against Hepatitis B Virus (HBV) in HIV-1-Infected Patients With Isolated Anti-HBV Core Antibody: The ANRS HB EP03 CISOVAC Prospective Study.

6533b830fe1ef96bd1297a6f

RESEARCH PRODUCT

Vaccination Against Hepatitis B Virus (HBV) in HIV-1-Infected Patients With Isolated Anti-HBV Core Antibody: The ANRS HB EP03 CISOVAC Prospective Study.

David Zucman Lionel Piroth Faiza Ajana David Rey Odile Launay Fabrice Carrat Fabrice Carrat Catherine Chirouze Dani Nazzal Marie-louise Michel Abderrahmane Bourredjem Marie-josée Wendling Christine Binquet Patrick Miailhes

subject

Adult Male Human immunodeficiency virus (HIV)HIV Infections medicine.disease_cause Virus Serology 03 medical and health sciences 0302 clinical medicine Immunogenicity Vaccine [ SDV.MP ] Life Sciences [q-bio]/Microbiology and Parasitology Antiretroviral Therapy Highly Active Hepatitis B virus HBV Immunology and Allergy Medicine Humans Hepatitis B Vaccines 030212 general & internal medicine Prospective Studies Hepatitis B Antibodies Prospective cohort study [SDV.MP] Life Sciences [q-bio]/Microbiology and Parasitology Vaccines Synthetic biology business.industry Immunogenicity virus diseases Middle Aged Hepatitis B Virology Hepatitis B Core Antigens digestive system diseases Vaccination Infectious Diseases [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology Immunology biology.protein HIV-1 030211 gastroenterology & hepatology Female Antibody business

description

International audience; Although an isolated anti-hepatitis B virus (HBV) core antibody (anti-HBc) serological profile is frequent in human immunodeficiency virus (HIV)-infected patients, data on HBV vaccination in these patients are scarce. A prospective multicenter study was conducted to assess the immunogenicity of HBV vaccination in 54 patients with an isolated anti-HBc profile and undetectable HIV load. They were vaccinated with 1 dose (20 µg) of recombinant HBV vaccine. Those with an anti-HBV surface antibody (anti-HBs) level of 100 mIU/mL 4 weeks after a single recall dose of HBV vaccine should be further vaccinated with a reinforced triple double-dose scheme.

year	journal	country	edition	language
2016-01-14

https://hal.archives-ouvertes.fr/hal-01309269

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