Proteomics Reveals the Potential Protective Mechanism of Hydrogen Sulfide on Retinal Ganglion Cells in an Ischemia/Reperfusion Injury Animal Model

6533b830fe1ef96bd1297aeb

RESEARCH PRODUCT

Proteomics Reveals the Potential Protective Mechanism of Hydrogen Sulfide on Retinal Ganglion Cells in an Ischemia/Reperfusion Injury Animal Model

Verena Prokosch Caroline Manicam Natarajan Perumal Hanhan Liu Karl Mercieca

subject

0301 basic medicine neuronal apoptosis genetic structures Quantitative proteomics hydrogen sulfide Pharmaceutical Science lcsh:Medicine lcsh:RS1-441 Pharmacology Proteomics Retinal ganglion Article label-free mass spectrometry lcsh:Pharmacy and materia medica 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine mitochondrial function In vivo Drug Discovery medicine Retina Chemistry lcsh:R Retinal medicine.disease equipment and supplies eye diseases 030104 developmental biology medicine.anatomical_structure glaucoma Retinal ganglion cell Molecular Medicine sense organs Reperfusion injury signalling pathways 030217 neurology & neurosurgery

description

Glaucoma is the leading cause of irreversible blindness and is characterized by progressive retinal ganglion cell (RGC) degeneration. Hydrogen sulfide (H2S) is a potent neurotransmitter and has been proven to protect RGCs against glaucomatous injury in vitro and in vivo. This study is to provide an overall insight of H2S&rsquo

year	journal	country	edition	language
2020-08-27	Pharmaceuticals

10.3390/ph13090213 http://dx.doi.org/10.3390/ph13090213

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