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RESEARCH PRODUCT
Exploring the Virchow-Robin spaces function: A unified theory of brain diseases.
Ekkehard M. KasperGiovanni GrassoIype CherianMargarita BeltranSunil MunokamiBinod Bhattaraisubject
Pathologymedicine.medical_specialtyTraumatic brain injury0206 medical engineeringCentral nervous systemVirchow robin spaces02 engineering and technologyDiseaseSurgical Neurology International: Neuroanatomy and Neurophysiology03 medical and health sciences0302 clinical medicineCerebrospinal fluidmedicinechronic traumatic encephalopathyparavascular pathwayPathologicalbusiness.industryVirchow–Robin spacemedicine.disease020601 biomedical engineeringcisternostomyChronic traumatic encephalopathymedicine.anatomical_structureSurgeryNeurology (clinical)Alzheimer diseaseVirchow–Robin spacesAlzheimer's diseaseErratumbusinessNeuroscience030217 neurology & neurosurgerydescription
Background: Cerebrospinal fluid (CSF) transport across the central nervous system (CNS) is no longer believed to be on the conventional lines. The Virchow-Robin space (VRS) that facilitates CSF transport from the basal cisterns into the brain interstitial fluid (ISF) has gained interest in a whole new array of studies. Moreover, new line of evidence suggests that VRS may be involved in different pathological mechanisms of brain diseases. Methods: Here, we review emerging studies proving the feasible role of VRS in sleep, Alzheimer's disease, chronic traumatic encephalopathy, and traumatic brain injury (TBI). Results: In this study, we have outlined the possible role of VRS in different pathological conditions. Conclusion: The new insights into the physiology of the CSF circulation may have important clinical relevance for understanding the mechanisms underlying brain pathologies and their cure. ©2016 Surgical Neurology International | Published by Wolters Kluwer - Medknow .
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2016-01-01 | Surgical neurology international |