Superagonistic CD28 stimulation induces IFN‐γ release from mouse T helper 1 cells in vitro and in vivo

6533b830fe1ef96bd1297d68

RESEARCH PRODUCT

Superagonistic CD28 stimulation induces IFN‐γ release from mouse T helper 1 cells in vitro and in vivo

Daniela Langenhorst Tim Sparwasser Niklas Beyersdorf Jan Schlegel Markus Sauer Stephanie Haack Sarah Baiker

subject

0301 basic medicine medicine.drug_class Immunology ved/biology.organism_classification_rank.species CD40 Ligand Stimulation chemical and pharmacologic phenomena Biology Monoclonal antibody Lymphocyte Activation 03 medical and health sciences Interferon-gamma Mice 0302 clinical medicine Immune system CD28 Antigens In vivo medicine Immunology and Allergy Animals Humans Secretion ddc:610 CD40 Antigens Model organism ved/biology CD28 Antibodies Monoclonal hemic and immune systems Th1 Cells In vitro Cell biology 030104 developmental biology 030215 immunology Signal Transduction

description

Like human Th1 cells, mouse Th1 cells also secrete IFN-γ upon stimulation with a superagonistic anti-CD28 monoclonal antibody (CD28-SA). Crosslinking of the CD28-SA via FcR and CD40-CD40L interactions greatly increased IFN-γ release. Our data stress the utility of the mouse as a model organism for immune responses in humans.

year	journal	country	edition	language
2020-06-08

10.1002/eji.202048803 https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-239028

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