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RESEARCH PRODUCT
285 DOWNREGULATION OF ORGANIC CATION TRANSPORTERS OCT1 (SLC22A1) AND OCT3 (SLC22A3) IN HUMAN HEPATOCELLULAR CARCINOMA AND THEIR PROGNOSTIC SIGNIFICANCE
Michael HeiseJ KnapsteinGerd OttoJm SchattenbergTim ZimmermannAnja LautemM. SchuchmannPeter R. Gallesubject
Organic cation transport proteinsgenetic structuresHepatologybiologyChemistryTransportermedicine.diseaseeye diseasesSLC22A3Downregulation and upregulationHepatocellular carcinomaCancer researchmedicinebiology.proteinsense organsCytotoxicityTyrosine kinaseIntracellulardescription
Background Organic cation transporters (OCT) are responsible for the uptake and intracellular inactivation of a broad spectrum of endogenous substrates and detoxification of xenobiotics and chemotherapeutics. The transporters became pharmaceutically interesting, because OCTs are determinants of the cytotoxicity of platin derivates and the transport activity has been shown to correlate with the sensitivity of tumors towards tyrosine kinase inhibitors. No data exist about the relevance of OCTs in hepatocellular carcinoma (HCC).
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2012-04-01 | Journal of Hepatology |