6533b831fe1ef96bd129846f
RESEARCH PRODUCT
Synthesis of tritiated derivatives of the diphenylether herbicides acifluorfen and acifluorfen methyl
René ScallaLucien GouinColin SwithenbankRené MornetMichel Matringesubject
Stereochemistry[SDV]Life Sciences [q-bio]Nitro compoundEtherAcifluorfenBiochemistryAnalytical Chemistry03 medical and health scienceschemistry.chemical_compoundMALHERBOLOGIEDrug DiscoveryPIPHENYL ETHERRadiology Nuclear Medicine and imagingSYNTHESESpectroscopyComputingMilieux_MISCELLANEOUS030304 developmental biologychemistry.chemical_classification0303 health sciencesTrifluoromethyl030302 biochemistry & molecular biologyOrganic Chemistry3. Good health[SDV] Life Sciences [q-bio]Enzyme inhibitionEnzymeAcifluorfen-methylchemistryProtoporphyrinogen oxidaseCHIMIE ORGANIQUEdescription
Acifluorfen 1 and acifluorfen methyl 2, two herbicides of the diphenylether family, are inhibitors of protoporphyrinogen oxidases. Two tritiated derivatives of these compounds, namely 3-[3H]-5-[2-chloro-4-(trifluoromethyl)phenoxy]-2-nitrobenzoic acid [3H]-1, and methyl 3-[3H]-5-[2-chloro-4-(trifluoromethyl)phenoxy]-2-nitrobenzoic acid [3H]-2, have been synthesised from 3-[3H]-5-hydroxybenzoic acid, in order to probe their interactions with the target enzymes.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1992-03-01 |