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RESEARCH PRODUCT

Bioactive aristolactams from Piper umbellatum.

Marie Aleth Lacaille-duboisSheraz A. K. TanoliBang LuuJiawei LiuAnne Claire Mitaine-offerTuribio Kuiate TabopdaJoseph NgoupayoBonaventure T. NgadjuiShamsun Nahar KhanEtienne TsamoMuhammad Ali

subject

Antifungal AgentsLactamsStereochemistryDPPHFriedelinPlant ScienceHorticultureBiochemistryHeterocyclic Compounds 4 or More Ringschemistry.chemical_compoundAlkaloidsMolecular BiologyPiperAcacetinbiologyMolecular StructurePlant ExtractsAlkaloidGeneral MedicineFree Radical ScavengersTyraminePiperaceaePlant Components Aerialbiology.organism_classificationchemistryApigeninPiper

description

Four alkaloids named piperumbellactams A-D (1-4) were isolated from branches of Piper umbellatum together with known N-hydroxyaristolam II (5), N-p-coumaroyl tyramine (6), 4-nerolidylcatechol (7), N-trans-feruloyltyramine, E-3-(3,4-dihydroxyphenyl)-N-2-[4-hydroxyphenylethyl]-2-propenamide, beta-amyrin, friedelin, apigenin 8-C-neohesperidoside, acacetin 6-C-beta-d-glucopyranoside, beta-sitosterol, its 3-O-beta-d-glucopyranoside and its 3-O-beta-d-[6'-dodecanoyl]-glucopyranoside. Glycosidase inhibition, antioxidant and antifungal activities of these compounds were evaluated. Compounds 1-3 showed moderate alpha-glucosidase enzyme inhibition with IC50 values 98.07+/-0.44, 43.80+/-0.56 and 29.64+/-0.46, respectively. In DPPH radical scavenging assay, compounds 2, 3 and 6 showed potent inhibitory activity while compounds 4, 5 and 7 showed potent antifungal activity.

10.1016/j.phytochem.2008.02.018https://pubmed.ncbi.nlm.nih.gov/18400239