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RESEARCH PRODUCT
Metastatic Renal Cell Carcinoma to Submandibular Gland: A Rare Occurrence
Adriana TuttolomondoNino DispensaGuglielmo MelloniCarlo MelloniAdriana Cordovasubject
Pathologymedicine.medical_specialtymedicine.medical_treatmentSettore MED/19 - Chirurgia PlasticaMetastasiurologic and male genital diseasesSettore MED/24 - UrologiaMetastasisstomatognathic systemRenal cell carcinomamedicineClear cell renal carcinomaSalivary gland metastasisSubmandibular glandKidneySalivary glandbusiness.industryGeneral Medicinemedicine.diseaseSubmandibular glandNephrectomymedicine.anatomical_structureLocalized diseaseClear cell renal carcinoma; Metastasis; Submandibular gland; Salivary gland metastasisbusinessClear celldescription
Approximately 20-30% of patients affected by renal cell carcinoma (RCC) present with metastatic disease, and 20% to 40% undergoing nephrectomy for clinically localized disease will develop metastases. A 53 years old female patient developed a left submandibular swelling. Four years before she experienced a left radical nephrectomy for a clear cell tumor and two years later right kidney was removed for a cancer having the same histologic subtype. In that circumstance duodenal pancreasectomy was required for infiltration of pancreatic gland. A sialoadenectomy has been performed and pathology demonstrated an intraglandular neoplasm with characteristics of a clear renal cell carcinoma. Although it is extremely rare, submandibular salivary gland may be a site of RCC metastasis. Diagnosis of metastatic disease for patients affected by submandibular swelling with a previous history of RCC should be always considered.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2015-09-05 | Anaplastology |