6533b831fe1ef96bd12986b1
RESEARCH PRODUCT
Endogenous oxytocin is essential for the buffering effects of pair housing against the increase in cocaine reward induced by social stress.
José MiñarroMarta Rodríguez-ariasMarina D. ReguilónCarmen Ferrer-pérezsubject
Malemedicine.medical_specialtymedicine.drug_classmedia_common.quotation_subjectExperimental and Cognitive PsychologyEndogenyOxytocinSocial defeat03 medical and health sciencesBehavioral NeuroscienceMice0302 clinical medicineCocaineRewardInternal medicinemedicineAnimals0501 psychology and cognitive sciences050102 behavioral science & comparative psychologySocial Behaviormedia_commonSocial stressbusiness.industryAddiction05 social sciencesAtosibanReceptor antagonistConditioned place preferenceEndocrinologyOxytocinHousingbusiness030217 neurology & neurosurgeryStress Psychologicalmedicine.drugdescription
Social factors have a dual influence on addictive disorders. While social defeat stress in rodents increases the response to drug reward, positive social conditions, such as pair housing, increase stress resilience. The objective of the present study was to confirm whether oxytocin (OT) mediates this social buffering. To this end, male mice were housed in pairs and administered the OT receptor antagonist atosiban prior to each stress episode or for ten days after the stress protocol. The response to cocaine was assessed using a conditioned place preference paradigm. Our results confirmed that OT activity mediates the protective effect of pair housing and highlights its therapeutic potential.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2019-12-19 | Physiologybehavior |