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RESEARCH PRODUCT

Chapter 27: Peptidergic and cholinergic receptors on cultured astrocytes of different regions of the rat CNS

Alfred MaelickeL. HösliElisabeth HösliH. Schröder

subject

CerebellumNeocortexDepolarizationBiologyElectrophysiologymedicine.anatomical_structureNicotinic agonistnervous systemMuscarinic acetylcholine receptormedicineCholinergicReceptorNeurosciencehormones hormone substitutes and hormone antagonists

description

Publisher Summary This chapter discusses whether astrocytes possess peptidergic and cholinergic receptors. There is strong evidence that in addition to neurons, astrocytes also express receptors for neurotransmitters and neuromodulators. The investigations were carried out in explant cultures of the spinal cord, brain-stem, cerebellum, and neocortex of fetal and newborn rats. By the means of autoradiography, it was demonstrated that astrocytes possess binding sites for the vasoactive peptides 3 H-Ang II, 125 I- VIP, 125 I-ET-l, ET-3, and 125 I-AVP. These findings are consistent with electrophysiological studies demonstrating that Ang II, ET, and AVP cause a depolarization of the glial membrane, whereas VIP had a hyperpolarizing action. Autoradiographic studies showed that astrocytes express binding sites for muscarinic and nicotinic cholinergic ligands.

yearjournalcountryeditionlanguage
1992-01-01
https://doi.org/10.1016/s0079-6123(08)61761-6