6533b831fe1ef96bd1298edc
RESEARCH PRODUCT
Chemical heterogeneity of amyloid in the carpal tunnel syndrome
K. SteinReinhold P. LinkeH. H. GoebelStephan Störkelsubject
musculoskeletal diseasesAmyloidPathologymedicine.medical_specialtyAmyloidBiopsyPathology and Forensic MedicinePathogenesismental disordersHumansMedicineCarpal tunnelSerum amyloid ACarpal tunnel syndromeMolecular BiologyRetrospective StudiesSerum Amyloid A ProteinImmunoperoxidasebiologyHistocytochemistrybusiness.industryAmyloidosisAmyloidosisCell BiologyGeneral Medicinemusculoskeletal systemmedicine.diseaseCarpal Tunnel SyndromeImmunohistochemistrybody regionsTransthyretinmedicine.anatomical_structurebiology.proteinbusinessdescription
140 biopsies from 108 patients afflicted with the carpal tunnel syndrome were studied, 27 of whom showed deposition of amyloid, in 6 of them to such an extent that the amyloid was considered significant in the pathogenesis of the carpal tunnel syndrome. Morphologically, vessels and ligaments were affected and especially the peritendinous structures. As it was always part of generalized amyloidosis, the amyloid in the carpal tunnel consisted immunohistologically of amyloid A in three cases (including one case with simultaneous amyloid deposition of the AA- and the AB-type), of amyloid A kappa in one case, of amyloid of prealbumin origin in seventeen cases and of AB-amyloid in eight cases. We also described for the first time the manifestation of generalized senile amyloidosis (ASs) in the carpal tunnel. Deposition of amyloid of beta-2-microglobulin type (AB) in the carpal tunnel was particularly frequent and massive.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1987-01-01 | Virchows Archiv A Pathological Anatomy and Histopathology |