Role of the basolateral amygdala in retrieval of conditioned flavors in the awake rat.

6533b831fe1ef96bd1298ee4

RESEARCH PRODUCT

Role of the basolateral amygdala in retrieval of conditioned flavors in the awake rat.

Luc Pénicaud Luc Pénicaud Luc Pénicaud Fabienne Liénard Fabienne Liénard Fabienne Liénard Frédérique Datiche Frédérique Datiche Frédérique Datiche Lucie Desmoulins Lucie Desmoulins Lucie Desmoulins

subject

Male medicine.medical_specialty Taste Action Potentials Amygdala Preference 03 medical and health sciences Behavioral Neuroscience Eating Food Preferences 0302 clinical medicine Internal medicine [SDV.IDA]Life Sciences [q-bio]/Food engineering Conditioning Psychological medicine Animals [SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering Rats Wistar Flavor 030304 developmental biology Neurons 0303 health sciences Basolateral Nuclear Complex food and beverages Taste Perception Signal Processing Computer-Assisted Amygdala Flavor Immunohistochemistry Electrodes Implanted Electrophysiology Electrophysiology medicine.anatomical_structure Endocrinology Glucose Oncogene Proteins v-fos Odor Awake rat Conditioning Psychology Food Deprivation Neuroscience Nucleus 030217 neurology & neurosurgery Basolateral amygdala Conditioning

description

International audience; Learned association between odor, taste and further post-ingestive consequence is known as flavor nutrient conditioned preference. Amygdala is supposed to be one of the areas involved in these associations. In the present study, one flavor was associated with a 16% glucose (CS+) whereas another flavor was paired with less reinforcing 4% glucose (CS-). We showed that CS+ presentation after conditioning increased Fos expression in the basolateral nucleus of amygdala (BLA). Furthermore, we performed electrophysiological recordings in the BLA in free moving rats. After preference acquisition, rats were exposed to either the CS+ or the CS-. The proportion of neurons showing a decreased activity during the CS- presentation was significantly higher in conditioned rats compared to controls. Among this neuronal population recorded in conditioned rats, we noticed a significant proportion of neurons that also showed a decreased activity during the CS+ presentation. Our data indicate an involvement of BLA during retrieval of learned flavors. It also suggests that both flavors might have acquired a biological value through conditioning.

year	journal	country	edition	language
2014-01-01	Behavioural brain research

10.1016/j.bbr.2014.03.034 https://pubmed.ncbi.nlm.nih.gov/24675157