6533b831fe1ef96bd1298fa4
RESEARCH PRODUCT
Monte Carlo simulation of DNA electrophoresis
Kurt KremerHarry L. FrischJannis BatoulisNorbert Pistoorsubject
ElectrophoresisPhysicsQuantitative Biology::BiomoleculesGel electrophoresis of nucleic acidsClinical BiochemistryMonte Carlo methodMarkov chain Monte CarloDNABiochemistryAnalytical ChemistryMolecular WeightHybrid Monte CarloElectrophoresissymbols.namesakeModels ChemicalsymbolsDynamic Monte Carlo methodComputer SimulationStatistical physicsGelsKappaMonte Carlo molecular modelingdescription
This paper describes an attempt to study the electrophoresis mobility of a DNA molecule in a gel by means of a Monte Carlo simulation. We find that the electrophoresis mobility mu can be well described by the empirical equation mu v kappa 1/N + kappa 2E2 with N being the number of monomers of the model chain and E being the applied field. For small E the data can merge into the linear response result mu = kappa 1/N. The paper also discusses necessary extensions of the present approach.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1989-05-01 | Electrophoresis |