Neurochemical alterations in women with borderline personality disorder and comorbid attention-deficit hyperactivity disorder

6533b831fe1ef96bd1298fa8

RESEARCH PRODUCT

Neurochemical alterations in women with borderline personality disorder and comorbid attention-deficit hyperactivity disorder

Miriam Boeker Jürgen Hennig Dieter Ebert Nicolas Rüsch Volkmar Glauche Ludger Tebartz Van Elst Martin Büchert Carl Bohrmann Klaus Lieb

subject

Adult Cerebellum medicine.medical_specialty Magnetic Resonance Spectroscopy Glutamine Glutamic Acid 610 Medicine & health 10056 Clinic for Clinical and Social Psychiatry Zurich West (former)Creatine Gyrus Cinguli behavioral disciplines and activities Choline 2738 Psychiatry and Mental Health chemistry.chemical_compound Glutamatergic Neurochemical Borderline Personality Disorder Cerebellum Internal medicine mental disorders medicine Humans Attention deficit hyperactivity disorder Borderline personality disorder Biological Psychiatry Brain Chemistry Aspartic Acid Glutamate receptor Creatine medicine.disease Glutamine Psychiatry and Mental health medicine.anatomical_structure Endocrinology chemistry Attention Deficit Disorder with Hyperactivity Case-Control Studies Psychology 2803 Biological Psychiatry Inositol Clinical psychology

description

Borderline personality disorder (BPD) is associated with structural and functional brain changes. Recent models and findings refer to alterations of glutamate and total N-acetylaspartate (tNAA) in this condition.Absolute quantities of tNAA, creatine, glutamate, glutamine, myoinositol and total choline were measured using 3 Tesla magnetic resonance spectroscopy of the left anterior cingulate cortex and the left cerebellum in 14 unmedicated women with BPD and comorbid attention-deficit hyperactivity disorder (ADHD) and 18 healthy women. Both groups were matched with respect to age, education and premorbid intelligence.In the anterior cingulate, we found significantly higher tNAA and glutamate concentrations and a trend for lower glutamine levels in women with BPD and comorbid ADHD as compared to healthy women. There were no significant group differences in cerebellar metabolite concentrations.Glutamatergic changes in the anterior cingulate may be associated with BPD and comorbid ADHD. Increased anterior cingulate tNAA may indicate disturbed energy metabolism or impaired frontal maturation.

year	journal	country	edition	language
2010-01-01	The World Journal of Biological Psychiatry

https://doi.org/10.3109/15622970801958331