6533b831fe1ef96bd1298fca
RESEARCH PRODUCT
Gut microbiota and aging-A focus on centenarians.
Manfredi RizzoNiki KatsikiDan Cristian VodnarAdriana Florinela CӑtoiAndra Diana AndreicuțAnca Pantea StoianAndreea CorinaPablo Perez-martinezsubject
0301 basic medicineSenescenceAgingSynbioticsmedia_common.quotation_subjectLongevitySynbioticsGut microbiotaBiologyGut flora03 medical and health sciences0302 clinical medicineCentenariansHumansAging Centenarians Gut microbiota Prebiotics Probiotics Synbiotics Aged 80 and over Aging Gastrointestinal Microbiome Humans Longevity Prebiotics Probiotics SynbioticsMolecular Biologymedia_commonAged 80 and overProbioticsLongevityImmunosenescencebiology.organism_classificationGastrointestinal Microbiome030104 developmental biologyPrebioticsImmunologyMolecular Medicine030217 neurology & neurosurgerydescription
Gut microbiota (GM) is a dynamic organ throughout the lifespan. Aging is a complex process that comprises a plethora of mechanisms such as senescence, immunosenescence and inflammaging, representing important pathways of age-related diseases. GM structure could both influence and be influenced by aging occurring changes within the host. A unique category of long living individuals exists, namely centenarians that have the outstanding capacity to adapt to various challenges. Longevity seems to be associated with certain GM which, among other factors, might render individuals more resistant to age-related diseases and subsequently to long living. Diet, prebiotics, probiotics and synbiotics may contribute to longevity through GM modulating. Currently, the exact mechanisms of the association between GM and the host in relation with extended lifespan remain unknown and should be further investigated.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2020-03-10 |