6533b831fe1ef96bd1299087

RESEARCH PRODUCT

Binding of RNA Aptamers to Membrane Lipid Rafts: Implications for Exosomal miRNAs Transfer from Cancer to Immune Cells

Karolina SapońTeresa JanasPawel JanasTadeusz Janas

subject

liposomesendocrine systemmacromolecular substancesexosomesArticleCatalysisraftslcsh:ChemistryInorganic ChemistryMembrane LipidsMembrane Microdomainsimmune cellsCell Line TumorNeoplasmsmicroRNAHumansRNA aptamersPhysical and Theoretical Chemistrylcsh:QH301-705.5Molecular BiologyLipid raftSpectroscopyChemistrySELEXMacrophagesVesicleCell MembraneOrganic ChemistryMultivesicular BodiesRNA-Binding ProteinsRNADendritic CellsGeneral MedicineRaftAptamers NucleotideMicrovesiclesComputer Science ApplicationsCell biologyKiller Cells NaturalMicroRNAslcsh:Biology (General)lcsh:QD1-999Cancer cellmiRNAslipids (amino acids peptides and proteins)Systematic evolution of ligands by exponential enrichment

description

Intraluminal vesicles (ILVs) are released into the extracellular space as exosomes after the fusion of multivesicular bodies (MVBs) with the plasma membrane. miRNAs are delivered to the raft-like region of MVB by RNA-binding proteins (RBPs). RNA loading into exosomes can be either through direct interaction between RNA and the raft-like region of the MVB membrane, or through interaction between an RBP&ndash

yearjournalcountryeditionlanguage
2020-11-01International Journal of Molecular Sciences
10.3390/ijms21228503https://doi.org/10.3390/ijms21228503