6533b831fe1ef96bd1299160
RESEARCH PRODUCT
In situ formation of steroidal supramolecular gels designed for drug release
Erkki KolehmainenHana Bunzensubject
In situMagnetic Resonance SpectroscopykolesteroliImineSupramolecular chemistryPharmaceutical ScienceArticleChloroquinolinolsAnalytical ChemistryDelayed-Action Preparationslcsh:QD241-441chemistry.chemical_compoundgeeliDrug Delivery Systemslcsh:Organic chemistryDrug DiscoveryPolymer chemistryMoleculeddc:530Physical and Theoretical Chemistryta116drug releaseOrganic ChemistryorganogelcholesterolNuclear magnetic resonance spectroscopyacid-responsiveHydrogen-Ion ConcentrationchemistryChemistry (miscellaneous)in situ gelationDelayed-Action PreparationsDrug deliveryDrug releaseMolecular Medicineorganogel; acid-responsive; cholesterol; <i>in situ</i> gelation; drug releaseGelsdescription
In this work, a steroidal gelator containing an imine bond was synthesized, and its gelation behavior as well as a sensitivity of its gels towards acids was investigated. It was shown that the gels were acid-responsive, and that the gelator molecules could be prepared either by a conventional synthesis or directly in situ during the gel forming process. The gels prepared by both methods were studied and it was found that they had very similar macroand microscopic properties. Furthermore, the possibility to use the gels as carriers for aromatic drugs such as 5-chloro-8-hydroxyquinoline, pyrazinecarboxamide, and antipyrine was investigated and the prepared two-component gels were studied with regard to their potential applications in drug delivery, particularly in a pH-controlled drug release. peerReviewed
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2013-03-01 |