6533b831fe1ef96bd12996cf
RESEARCH PRODUCT
Non-Steroidal Anti-Inflammatory Agents, Part 20[1] Method for Testing Non-Steroidal Anti-Inflammatories: The Modified Hen's Egg Chorioallantoic Membrane Test (HET-CAM Test) Compared to Other Procedures
Ulrike NoweGerd DannhardtAndreas PiesMareta Krehersubject
KetoprofenStereochemistryPharmaceutical SciencePharmacologyPiroxicamchemistry.chemical_compoundChorioallantoic membraneFlufenamic acidDiclofenacchemistryDrug DiscoveryPhenylbutazonemedicineSodium salicylateSalicylic acidmedicine.drugdescription
The delay of onset of irritation phenomena at the chorioallantoic membrane of incubated hen's eggs, a parameter for anti-inflammatory activity, was determined for the pharmaceutical substances diclofenac, flufenamic acid, ibuprofen, indomethacin, ketoprofen, piroxicam, phenylbutazone, salicylic acid, and sodium salicylate. Alongside questions relating to the dose-effect ratio, metabolisation, recovery, and diffusion of the substances to their site of action were investigated. The reproducibility of the procedure and its selectivity with regard to substances with a different mechanism of action is proven. The method allows classification of the substances according to their anti-inflammatory potency. However, correlation with the results of enzyme inhibition or in vivo results is only possible to a limited extent.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1996-01-01 | Archiv der Pharmazie |