Safety and efficacy of buparlisib (BKM120) and chemotherapy in advanced, squamous non-small cell lung cancer (sqNSCLC): Results from the phase Ib/II BASALT-2 and BASALT-3 studies.

6533b831fe1ef96bd1299705

RESEARCH PRODUCT

Safety and efficacy of buparlisib (BKM120) and chemotherapy in advanced, squamous non-small cell lung cancer (sqNSCLC): Results from the phase Ib/II BASALT-2 and BASALT-3 studies.

Jaafar Bennouna Enriqueta Felip Diego Cortinovis Arunava Chakravartty Juergen Alt Eric Scott Schaefer Marie Chol Alessandro Morabito Alex A. Adjei Francesco Grossi Paola Aimone Luis Paz-ares David Planchard Joan Maier Javier De Castro Tommaso De Pas Natasha B. Leighl Christos Chouaid Michael Thomas

subject

0301 basic medicine Basalt Cancer Research Chemotherapy business.industry medicine.medical_treatment Buparlisib 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology 0302 clinical medicine Oncology chemistry 030220 oncology & carcinogenesis Squamous non-small cell lung cancer Cancer research medicine Phosphatidylinositol business PI3K/AKT/mTOR pathway

description

e20522Background: Phosphatidylinositol 3-kinase (PI3K) pathway activation may contribute to primary and secondary resistance to platinum (Pt)-based chemotherapy (CT) in sqNSCLC. The pan-PI3K inhibi...

year	journal	country	edition	language
2016-05-20	Journal of Clinical Oncology

https://doi.org/10.1200/jco.2016.34.15_suppl.e20522

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