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RESEARCH PRODUCT
Mononuclear heterocyclic rearrangements. Part 12. Rearrangement of 1,2,4-oxadiazoles into indazoles
Nicolò VivonaVincenzo FrennaMichele RucciaGiuseppe CusmanoGabriella Macalusosubject
StereochemistryChemistryOrganic ChemistryBase (exponentiation)Sequence (medicine)description
The first example of a mononuclear heterocyclic rearrangement involving an XYZ = CCN side-chain sequence is reported. The 3-(o-aminophenyl)-, and 3-(o-methylaminophenyl)-5-methyl-1,2,4-oxadiazoles (3a,b) gave a thermally induced rearrangement into 3-acylaminoindazoles (4a,b). On the other hand, the 3-(o-acetylaminophenyl)-5-methyl-1,2,4-oxadiazole (3c) produced a base induced rearrangement into 3-acetylaminoindazole (4a).
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1979-06-01 | Journal of Heterocyclic Chemistry |