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RESEARCH PRODUCT

Positron Annihilation in Medical Substances of Insulin

subject

description

Positrons lifetimes were measured in medical substances of insulin (human and animal), differing as far as the degree of purity and time of their activity in the organism are concerned. In all of the cases the spectrum of positron lifetime was distributed into three components, with the long-life component ranging from 1.8 to 2.08 ns and the intensity taking on values from 18 to 24%. Making use of Tao–Eldrup model, the average radius of the free volume, in which o-Ps annihilated, and the degree of filling in the volume were determined. It was found that the value of the long-life component for human insulin is higher than that of animal insulin. Moreover, the value of this component clearly depends on the manner of purification of the insulin. It was also noticed that there occurs a correlation between the value of this component and the time after which it begins to be active in the organism, as well as the total time of its activity.