6533b831fe1ef96bd12997e9
RESEARCH PRODUCT
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subject
0303 health sciencesMolecular interactionsNucleoplasmbiologyParvovirusviruses030302 biochemistry & molecular biologyParvovirus infectionbiology.organism_classificationmedicine.diseaseCell biology03 medical and health scienceschemistry.chemical_compoundInfectious Diseasesmedicine.anatomical_structureCapsidchemistryVirologyDNA ModificationmedicineNucleusDNA030304 developmental biologydescription
Parvoviruses are small single-stranded (ss) DNA viruses, which replicate in the nucleoplasm and affect both the structure and function of the nucleus. The nuclear stage of the parvovirus life cycle starts at the nuclear entry of incoming capsids and culminates in the successful passage of progeny capsids out of the nucleus. In this review, we will present past, current, and future microscopy and biochemical techniques and demonstrate their potential in revealing the dynamics and molecular interactions in the intranuclear processes of parvovirus infection. In particular, a number of advanced techniques will be presented for the detection of infection-induced changes, such as DNA modification and damage, as well as protein–chromatin interactions.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2021-07-05 | Viruses |