6533b831fe1ef96bd12998b0
RESEARCH PRODUCT
Two mixed valence diruthenium(ii,iii) isomeric complexes show different anticancer properties
Tiziano MarzoIogann TolbatovAlessandro MarroneNazzareno ReSabrina TalianiElisabetta BarresiElisa ZappelliClaudia MartiniDiego La MendolaAlessandro PratesiFederico Da Settimosubject
Inorganic ChemistrySteric effectsValence (chemistry)StereochemistryChemistrymedicinemedicine.diseaseGlioblastomadescription
In this paper it is demonstrated that the nature of the ligands of two Ru2(II,III) paddlewheel complexes dramatically affects the overall anticancer properties in cells. Herein, the complex [Ru2(EB776)4Cl] was found to be more active against a glioblastoma model with respect to its isomer [Ru2(EB106)4Cl]. These different effects depend on the steric hindrance, on the allowed conformations of the complexes and on the presence of hydrophilic regions in [Ru2(EB776)4Cl], which overall lead to a lower “steric protection”.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2021-06-24 |