6533b831fe1ef96bd12998b7
RESEARCH PRODUCT
Blood, breast milk and urine: potential biomarkers of exposure and estimated daily intake of ochratoxin A: a review.
Ana Juan-garcíaLara ManyesJulia Bellver SotoMaría-josé Ruizsubject
Ochratoxin ADaily intakeHealth Toxicology and MutagenesisFood ContaminationUrineBreast milkToxicologyToxicologychemistry.chemical_compoundMedicineHumansFood scienceMycotoxinMilk HumanMolecular Structurebusiness.industryPublic Health Environmental and Occupational HealthGeneral ChemistryGeneral MedicineEnvironmental ExposureOchratoxinsSpanish populationchemistryPotential biomarkersFood productsbusinessBiomarkersFood Sciencedescription
The purposes of this review are to study potential biomarkers of exposure for ochratoxin A (OTA) in biological fluids (blood, urine and breast milk) for the period 2005-14, calculate the estimated daily intake (EDI) of OTA by using database consumption for the Spanish population, and, finally, to correlate OTA levels detected in blood and EDI values calculated from food products. The values of OTA detected in potential biomarkers of exposure for blood, breast milk and urine ranged from 0.15 to 18.0, from 0.002 to 13.1, and from 0.013 to 0.2 ng ml(-1), respectively. The calculated EDI for OTA in plasma ranged from 0.15 to 26 ng kg(-1) bw day(-1), higher than that obtained in urine (0.017-0.4 ng kg(-1) bw day(-1)). All these values are correlated with the range of EDI for OTA calculated from food products: 0.0001-25.2 ng kg(-1) bw day(-1).
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2015-11-14 | Food additivescontaminants. Part A, Chemistry, analysis, control, exposurerisk assessment |