6533b831fe1ef96bd1299afb
RESEARCH PRODUCT
Synthesis of substituted isoindolo[2,1-a]quinoxalin-6-yl–amino and 6-imino-5-yl thiourea derivatives
Anna CarboneVirginia SpanòGirolamo CirrincioneBarbara ParrinoPatrizia DianaCristina CianciminoChandrakant SarwadeAlessandra MontalbanoSpanòPaola Barrajasubject
lcsh:QD241-441chemistry.chemical_compoundThiourealcsh:Organic chemistryChemistry1-a]quinoxalinesOrganic Chemistryisoindolo[21-a]quinoxalinesisoindolo[2; 1-a]quinoxalinesMedicinal chemistryisoindolo[2description
A series of substituted 1-(5-bromopyridin-2-yl)-3-[2-(isoindolo[2,1-a]quinoxalin-6- ylamino)ethyl]thiourea and 1-(5-bromopyridin-2-yl)-3-[2-(6-iminoisoindolo[2,1-a]quinoxalin- 5(6H)-yl)ethyl]thiourea derivatives were prepared in good yields (63-85%) by reaction between the corresponding amino compounds with 5-bromo-2-isothiocyanatopyridine. All thiourea derivatives, tested for inhibition of HIV-1 RT, showed no significant antiviral activity.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2014-01-01 | ARKIVOC |