Sequential BMP7/TGF-β1 signaling and microbiota instruct mucosal Langerhans cell differentiation

6533b831fe1ef96bd1299afc

RESEARCH PRODUCT

Sequential BMP7/TGF-β1 signaling and microbiota instruct mucosal Langerhans cell differentiation

Luba Eli-berchoer Martin Zenke Gili Zilberman-schapira Oded Heyman Björn E. Clausen Maria Nassar Maayan Levy Katya Zelentova Tal Capucha Thomas Hieronymus Noam Koren Asaf Wilensky Herve Bercovier Avi-hai Hovav Eran Elinav Tsipora Nir

subject

Male 0301 basic medicine Langerhans cell Bone Morphogenetic Protein 7 Immunology Receptor Transforming Growth Factor-beta Type I Biology Article 311 Transforming Growth Factor beta1 Mice 03 medical and health sciences Downregulation and upregulation 319 Langerhans cell differentiation medicine Animals Humans Immunology and Allergy Lectins C-Type Immunity Mucosal Research Articles Bone Morphogenetic Protein Receptors Type I Mice Knockout Lamina propria integumentary system Microbiota Stem Cells Mouth Mucosa Mucous membrane Cell Differentiation Epithelium Up-Regulation Cell biology Mice Inbred C57BL Bone morphogenetic protein 7 Mannose-Binding Lectins 030104 developmental biology medicine.anatomical_structure Langerhans Cells Antigens Surface Signal transduction Transcriptome Signal Transduction

description

Capucha et al. demonstrate that mucosal Langerhans cell (LC) differentiation from pre–dendritic cells and monocytes involves consecutive BMP7 and TGF-β1 signaling in separate anatomical locations. Moreover, mucosal microbiota regulates the development of LCs that in turn shape microbial and immunological homeostasis.

year	journal	country	edition	language
2018-01-17	Journal of Experimental Medicine

https://doi.org/10.1084/jem.20171508

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