0000000000780575

AUTHOR

Martin Zenke

showing 4 related works from this author

Sequential BMP7/TGF-β1 signaling and microbiota instruct mucosal Langerhans cell differentiation

2018

Capucha et al. demonstrate that mucosal Langerhans cell (LC) differentiation from pre–dendritic cells and monocytes involves consecutive BMP7 and TGF-β1 signaling in separate anatomical locations. Moreover, mucosal microbiota regulates the development of LCs that in turn shape microbial and immunological homeostasis.

Male0301 basic medicineLangerhans cellBone Morphogenetic Protein 7ImmunologyReceptor Transforming Growth Factor-beta Type IBiologyArticle311Transforming Growth Factor beta1Mice03 medical and health sciencesDownregulation and upregulation319Langerhans cell differentiationmedicineAnimalsHumansImmunology and AllergyLectins C-TypeImmunity MucosalResearch ArticlesBone Morphogenetic Protein Receptors Type IMice KnockoutLamina propriaintegumentary systemMicrobiotaStem CellsMouth MucosaMucous membraneCell DifferentiationEpitheliumUp-RegulationCell biologyMice Inbred C57BLBone morphogenetic protein 7Mannose-Binding Lectins030104 developmental biologymedicine.anatomical_structureLangerhans CellsAntigens SurfaceSignal transductionTranscriptomeSignal TransductionJournal of Experimental Medicine
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Ovine Carotid Artery-Derived Cells as an Optimized Supportive Cell Layer in 2-D Capillary Network Assays

2014

PLoS one 9(3), e91664 (2014). doi:10.1371/journal.pone.0091664

Vascular Endothelial Growth Factor APathologyCellBecaplerminlcsh:MedicineCardiovascularUmbilical veinUmbilical CordDrug DiscoveryMolecular Cell BiologyBiological Systems EngineeringMyocyteCardiovascular Imaginglcsh:ScienceMultidisciplinaryProto-Oncogene Proteins c-sisAnimal ModelsFlow CytometryEndothelial stem cellBevacizumabmedicine.anatomical_structureCarotid ArteriesMonoclonalMedicineImmunohistochemical AnalysisResearch ArticleBiotechnologymedicine.medical_specialtyCell typeDrugs and DevicesDrug Research and DevelopmentMyocytes Smooth MuscleImmunologyBiomedical EngineeringBioengineeringBiologyAntibodies Monoclonal HumanizedCell LineModel OrganismsVascular Biologymedicine.arterymedicineAnimalsHumansBiologySheeplcsh:REndothelial CellsFeeder CellsUmbilical arteryMolecular biologyVascular Endothelial Growth Factor Receptor-2Coculture TechniquesCapillariesCell cultureImmunologic Techniqueslcsh:QCytometry
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Induced Pluripotent Mesenchymal Stromal Cell Clones Retain Donor-derived Differences in DNA Methylation Profiles

2012

Reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) is an epigenetic phenomenon. It has been suggested that iPSC retain some tissue-specific memory whereas little is known about interindividual epigenetic variation. We have reprogrammed mesenchymal stromal cells from human bone marrow (iP-MSC) and compared their DNA methylation profiles with initial MSC and embryonic stem cells (ESCs) using high-density DNA methylation arrays covering more than 450,000 CpG sites. Overall, DNA methylation patterns of iP-MSC and ESC were similar whereas some CpG sites revealed highly significant differences, which were not related to parental MSC. Furthermore, hypermethylation in iP-MSC…

Induced Pluripotent Stem CellsBiologyDrug DiscoveryGeneticsHumansEpigeneticsCancer epigeneticsInduced pluripotent stem cellMolecular BiologyPharmacologyMesenchymal Stromal CellsReverse Transcriptase Polymerase Chain ReactionMesenchymal Stem CellsMethylationDNA MethylationFlow CytometryMolecular biologyEmbryonic stem cellImmunohistochemistryClone CellsCpG siteDNA methylationMolecular MedicineOriginal ArticleCpG IslandsReprogrammingMolecular Therapy
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Astrocytic Calcium Waves Signal Brain Injury to Neural Stem and Progenitor Cells

2017

Summary Brain injuries, such as stroke or trauma, induce neural stem cells in the subventricular zone (SVZ) to a neurogenic response. Very little is known about the molecular cues that signal tissue damage, even over large distances, to the SVZ. Based on our analysis of gene expression patterns in the SVZ, 48 hr after an ischemic lesion caused by middle cerebral artery occlusion, we hypothesized that the presence of an injury might be transmitted by an astrocytic traveling calcium wave rather than by diffusible factors or hypoxia. Using a newly established in vitro system we show that calcium waves induced in an astrocytic monolayer spread to neural stem and progenitor cells and increase th…

Male0301 basic medicineTime FactorsNotch signaling pathwaySubventricular zonechemistry.chemical_elementBiologyCalciumcalcium signalingBiochemistryArticleMice03 medical and health sciencesAdenosine TriphosphateNeural Stem CellsDownregulation and upregulationCell MovementGeneticsmedicineAnimalsCell Self RenewalProgenitor celllcsh:QH301-705.5Cells CulturedCalcium signalinglcsh:R5-920Gene Expression ProfilingastrocytesGap JunctionsCell DifferentiationCell BiologyAnatomyHypoxia (medical)strokeNeural stem cellDisease Models Animal030104 developmental biologymedicine.anatomical_structurelcsh:Biology (General)chemistryBrain InjuriesCalciummedicine.symptomFunction and Dysfunction of the Nervous Systemlcsh:Medicine (General)TranscriptomeNeurosciencenotchDevelopmental BiologyStem Cell Reports
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