1-(2′-Bromobenzyl)-6,7-dihydroxy-N-methyl-tetrahydroisoquinoline and 1,2-Demethyl-nuciferine as Agonists in Human D2 Dopamine Receptors

6533b832fe1ef96bd129a192

RESEARCH PRODUCT

1-(2′-Bromobenzyl)-6,7-dihydroxy-N-methyl-tetrahydroisoquinoline and 1,2-Demethyl-nuciferine as Agonists in Human D2 Dopamine Receptors

Diego Cortes Patrice Marques Marián Castro Maria-jesus Sanz Nuria Cabedo Laura Vila Laura Moreno Andrea G. Silva Mabel Loza

subject

Pharmacology D2 dopamine receptors Antiparkinsonian drugs Nuciferine 010405 organic chemistry Tetrahydroisoquinoline Organic Chemistry Pharmaceutical Science Pharmacology 01 natural sciences Partial agonist 0104 chemical sciences Analytical Chemistry 010404 medicinal & biomolecular chemistry chemistry.chemical_compound Complementary and alternative medicine chemistry Dopamine receptor Drug Discovery Molecular Medicine

description

Certain D2-like dopamine receptor (DR) agonists are useful therapeutically as antiparkinsonian drugs, whereas D2-like DR antagonists or partial agonists are proven effective as antipsychotics. Two ...

year	journal	country	edition	language
2020-01-14	Journal of Natural Products

https://doi.org/10.1021/acs.jnatprod.9b00921

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