6533b832fe1ef96bd129a1d2

RESEARCH PRODUCT

949 IDENTIFICATION OF TWO CLINICALLY DISTINCT SUBTYPES IN AUTOIMMUNE HEPATITIS BY COMPARATIVE FUNCTIONAL GENOMICS

Eckart SchottL.a. ConnerJesper B. AndersenI. EickmeierJens U. MarquardtAndreas TeufelDaniel SeidelTorsten HansenSnorri S. ThorgeirssonD BeckerP. PlochT GamstätterPeter R. Galle

subject

HepatologyAntigenImmunologyImmune regulationmedicineIdentification (biology)Autoimmune hepatitisBacterial antigenBiologyReceptorBioinformaticsmedicine.diseaseFunctional genomics

description

Conclusion: Incidence of autoimmune hepatitis is increasing, as other autoimmune diseases in developed countries. The main recognised hypothesis is the ‘hygienist theory’ (improvement of hygien leading to a decrease in infections) with few putative non exclusive mechanisms involving antigenic competition, extension of immune regulation induced by exogenous bacterial antigen or Toll Like Receptors.

yearjournalcountryeditionlanguage
2013-04-01Journal of Hepatology
https://doi.org/10.1016/s0168-8278(13)60951-4