ChemInform Abstract: Fluorous TBAF: A Convenient and Selective Reagent for Fluoride-Mediated Deprotections.

6533b832fe1ef96bd129a27f

RESEARCH PRODUCT

ChemInform Abstract: Fluorous TBAF: A Convenient and Selective Reagent for Fluoride-Mediated Deprotections.

Amador Garcia Sancho Jose Luis Acena Santos Fustero Juan F. Sanz-cervera

subject

chemistry.chemical_compound chemistry Reagent Organic chemistry Molecule Reactivity (chemistry)General Medicine Bifunctional Fluoride

description

A fluorous analogue of TBAF has been developed for its use in the clean removal of silicon-derived protecting groups. Purification of the crude mixtures by fluorous solid-phase extractions allowed alcohols, amines, and carboxylic acids to be obtained in high purity, with no need of chromatographic separations. The moderate reactivity of fluorous TBAF was exploited in selective deprotections of several bifunctional molecules.

year	journal	country	edition	language
2010-01-12	ChemInform

https://doi.org/10.1002/chin.201002055

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