6533b832fe1ef96bd129a45b

RESEARCH PRODUCT

A simple novel configuration for in-vial microporous membrane liquid–liquid extraction

Alberto ChisvertAmparo SalvadorJ.g. MarchJ. Palou

subject

Detection limitChromatographyAqueous solutionChemistryOrganic ChemistryExtraction (chemistry)Membranes ArtificialGeneral MedicineMicroporous materialChemical FractionationBiochemistryAnalytical ChemistryMembraneLiquid–liquid extractionPhase (matter)para-AminobenzoatesSample preparation4-Aminobenzoic AcidPorosity

description

Abstract A novel arrangement for microporous membrane liquid–liquid extraction from the aqueous donor phase to the organic acceptor phase within a micro-vial, which is compatible with the chromatograph autosampler is presented. The device consisted of a stoppered glass micro-vial containing the organic solvent where the septum of the screw stopper was replaced by a sized piece of membrane which is hermetically assembled to the volumetric flask containing the aqueous donor solution. The placement of the membrane in alternative contact with the solutions was achieved by orbital agitation. As a preliminary study, 2-ethylhexyl 4-(dimethylamino)benzoate has been determined (limit of quantification 0.11 μg L −1 , precision 7.4%). The small quantity of organic solvent used, the achieved sample cleanup, and the minimal handling and risk of cross-contamination are significant operational advantages.

yearjournalcountryeditionlanguage
2009-06-01Journal of Chromatography A
https://doi.org/10.1016/j.chroma.2009.04.082