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RESEARCH PRODUCT
Is group selection a factor modulating the virulence of RNA viruses?
Andrés MoyaSantiago F. ElenaRosario Mirallessubject
GeneticsModels GeneticVirulenceGenetic heterogeneityRNAVirulenceUnit of selectionGeneral MedicineViral quasispeciesBiologybiology.organism_classificationVesicular stomatitis Indiana virusGroup selectionGenetics PopulationVesicular stomatitis virusMultivariate AnalysisGeneticsRNA VirusesSelection GeneticSelection (genetic algorithm)description
RNA viruses consist of populations of extremely high genetic heterogeneity called quasispecies. Based on theoretical considerations, it has been suggested that the unit of selection in such complex genetic populations is not the single viral particle but a set of genetically related particles which form the quasispecies. In the present study we carried out a set of experiments with the vesicular stomatitis virus (VSV) dealing with the evolution of life-history characters under selection acting at two factors either in the same or in opposite directions. The two factors at which selective pressure is applied are the individual and the group. We show evidence that group selection modulates the virulence of VSV populations, in opposition to an unlimited increase in virulence by competitive optimization promoted by individual selection. The results are of relevance for understanding the evolution of parasite virulence.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1997-06-01 | Genetical research |