6533b832fe1ef96bd129a4f0

RESEARCH PRODUCT

Synthesis and antileukemic activity of new 3-(1-phenyl-3-methylpyrazol-5-yl)-2-styrylquinazolin-4(3H)-ones.

Benedetta MaggioGiuseppe DaidoneDemetrio RaffaStella CascioferroDomenico SchillaciFabiana Plescia

subject

Magnetic Resonance SpectroscopyStereochemistryHL60Pharmaceutical ScienceAntineoplastic AgentsHL-60 CellsAcetic acidchemistry.chemical_compoundStructure-Activity RelationshipDogshemic and lymphatic diseasesDrug Discoverymedicine3-(1-Phenyl-3-methylpyrazol-5-yl)-2-styrylquinazolin-4(3H)-oneAnimalsHumansLeukemia L1210LeukemiaGeneral Medicinemedicine.diseaseMolecular biologySettore CHIM/08 - Chimica FarmaceuticaIn vitroLeukemiachemistryCell cultureAntileukemic activityQuinazolinesIndicators and ReagentsBenzoic AldehydeK562 CellsCell DivisionChronic myelogenous leukemiaK562 cells

description

Abstract 3-(1-Phenyl-3-methylpyrazol-5-yl)-2-styrylquinazolin-4(3H)-ones 14a–q and 15a–q were synthesized by refluxing in acetic acid the corresponding 2-methylquinazolinones 12 and 13 with the opportune benzoic aldehyde for 12 h. The synthesized styrylquinazolinones 14a–q and 15a–q were tested in vitro for their antileukemic activity against L1210 (murine leukemia), K562 (human chronic myelogenous leukemia) and HL60 (human leukemia) cell lines showing in some cases good activity.

yearjournalcountryeditionlanguage
2004-07-06Farmaco (Societa chimica italiana : 1989)
10.1016/j.farmac.2003.10.004https://pubmed.ncbi.nlm.nih.gov/14987985