6533b832fe1ef96bd129a52b
RESEARCH PRODUCT
Long-term outcomes of patients with cerebral vein thrombosis: a multicenter study.
Dentali FPoli DScoditti UDi Minno M N DDe Stefano VStefano V DSiragusa SKostal MPalareti GSartori M TGrandone EVedovati M CAgeno WAnna FalangaLerede TeresaBianchi MarinaTesta SophieWitt DanMccool KatieBucherini EugenioGrifoni ElisaCoalizzo DanielaBenedetti RaffaellaMarietta MarcoSessa MariaGuaschino ClaraDi Minno GiovanniTufano AntonellaBarbar SofiaMalato AlessandraPini MarioCastellini PaolaBarco StefanoBarone MarisaMaurizio PaciaroniAlberti AndreaAgnelli GiancarloGiorgi Pierfranceschi MatteoDulicek PetrSilingardi MauroFederica LandiniGhirarduzzi AngeloTiraferri ErosDi Lazzaro VincenzoRossi ElenaCiminello AngelaSamantha PascaBarillari GiovanniEmanuele RezoagliGalli MatteoSquizzato AlessandroTosetto Albertosubject
AdultMalemedicine.medical_specialtyAnticoagulant treatment; Cerebral vein thrombosis; Mortality; Recurrence; Adult; Cerebral Veins; Cohort Studies; Female; Humans; Male; Middle Aged; Recurrence; ThrombosisCohort StudiesAnticoagulant treatment; Cerebral vein thrombosis; Mortality; RecurrenceRecurrenceInternal medicinemedicineRisk of mortalityHumansMED/41 - ANESTESIOLOGIAMortalitybusiness.industryIncidence (epidemiology)Cerebral Vein thrombosiHazard ratioCerebral VeinRetrospective cohort studyThrombosisHematologyMiddle Agedmedicine.diseaseThrombosisCerebral VeinsConfidence intervalSurgerycerebral vein thrombosisSettore MED/15 - MALATTIE DEL SANGUEThrombosiCohortFemaleAnticoagulant treatmentCohort StudiebusinessHumanCohort studydescription
Summary. Background: Little information is available on the long-term clinical outcome of cerebral vein thrombosis (CVT). Objectives and methods: In an international, retrospective cohort study, we assessed the long-term rates of mortality, residual disability and recurrent venous thromboembolism (VTE) in a cohort of patients with a first CVT episode. Results: Seven hundred and six patients (73.7% females) with CVT were included. Patients were followed for a total of 3171 patient-years. Median follow-up was 40 months (range 6, 297 months). At the end of follow-up, 20 patients had died (2.8%). The outcome was generally good: 89.1% of patients had a complete recovery (modified Rankin Score [mRS] 0–1) and 3.8% had a partial recovery and were independent (mRS 2). Eighty-four per cent of patients were treated with oral anticoagulants and the mean treatment duration was 12 months. CVT recurred in 31 patients (4.4%), and 46 patients (6.5%) had a VTE in a different site, for an overall incidence of recurrence of 23.6 events per 1000 patient-years (95% confidence Interval [CI] 17.8, 28.7) and of 35.1 events/1000 patient-years (95% CI, 27.7, 44.4) after anticoagulant therapy withdrawal. A previous VTE was the only significant predictor of recurrence at multivariate analysis (hazard ratio [HR] 2.70; 95% CI 1.25, 5.83). Conclusions: The long-term risk of mortality and recurrent VTE appears to be low in patients who survived the acute phase of CVT. A previous VTE history independently predicts recurrent events.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2012-01-01 | Journal of thrombosis and haemostasis : JTH |