6533b832fe1ef96bd129ad4b
RESEARCH PRODUCT
Inhibition of human T-cell leukemia virus type I replication in primary human T cells that express antisense RNA
T Von RüdenE Gilboasubject
DNA ReplicationT-LymphocytesvirusesGenetic VectorsImmunologyViral transformationVirus ReplicationMicrobiologyVirusCell LineRetrovirushemic and lymphatic diseasesVirologymedicineHumansRNA AntisenseHuman T-lymphotropic virus 1biologyRNAbiology.organism_classificationmedicine.diseaseVirologyMolecular biologyAntisense RNALeukemiaGene Expression RegulationViral replicationInsect ScienceHuman T-lymphotropic virus 1RNACell DivisionResearch Articledescription
The human T-cell leukemia virus type I is associated with adult T-cell leukemia-lymphoma in humans, a disease which is induced by a malignant transformation of T lymphocytes. Retrovirus vectors carrying human T-cell leukemia virus type I-derived sequences in reversed transcriptional orientation were used to express antisense RNA transcripts in primary human leukocytes. Human T-cell leukemia virus type I replication and virus-mediated immortalization were inhibited in cells harboring antisense constructs. This study suggests that retrovirus-mediated antisense RNA inhibition can be used to protect primary human T-lymphocytes from human T-cell leukemia virus type I-mediated cell transformation.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1989-02-01 | Journal of Virology |