6533b832fe1ef96bd129ae4f

RESEARCH PRODUCT

DIFFERENTIAL SCANNING CALORIMETRY STUDY ON DRUG RELEASE FROM AN INULIN-BASED HYDROGEL AND ITS INTERACTION WITH A BIOMEMBRANE MODEL:pH AND LOADING EFFECT

Francesco CastelliMaria Grazia SarpietroDorotea MicieliGaetano GiammonaSara OttimoGiuseppe TripodoBianca CarlisiGiovanna Pitarresi

subject

Magnetic Resonance SpectroscopyINULIN HYDROGELS DRUG RELEASE DIFFERENTIAL SCANNING CALORIMETRYPharmaceutical ScienceDiflunisalMethacrylic anhydrideCentrifugationInsulysinDosage formchemistry.chemical_compoundDifferential scanning calorimetryX-Ray DiffractionSpectroscopy Fourier Transform InfraredmedicineHypoglycemic AgentsChromatography High Pressure LiquidChromatographyCalorimetry Differential ScanningVesicleAnti-Inflammatory Agents Non-Steroidaltechnology industry and agricultureSuccinic anhydrideInulinHydrogelsMembranes ArtificialSuccinatesHydrogen-Ion ConcentrationDiflunisalControlled releaseMolecular WeightchemistryChemical engineeringSolubilitySelf-healing hydrogelsSpectrophotometry UltravioletChromatography Thin LayerDimyristoylphosphatidylcholinemedicine.drug

description

Inulin has been derivatized with methacrylic anhydride (MA) and succinic anhydride (SA) to obtain a methacrylated/succinilated derivative (INU-MA-SA) able to produce a pH sensitive hydrogel after UV irradiation. The hydrogel was characterized and loaded with diflunisal (10.4, 17 and 24%, w/w) chosen as a model drug. The drug release from INU-MA-SA-based hydrogel to a biomembrane model made by unilamellar vesicles of dimyristoylphosphatidyl-choline (DMPC) was investigated at pH 4.0 and 7.4 by differential scanning calorimetry (DSC) that appears to be a suitable technique to follow the transfer kinetics of a drug from a controlled release system to a biomembrane model. The drug release from the hydrogel was compared with the dissolution of drug solid form by examining the effects exerted on the thermotropic behaviour of the DMPC unilamellar vesicles. The transferred drug and the release rate were affected by the drug loading as well as by the pH of the external medium. In particular the release was not linearly related to the drug loading but an intermediate loading allowed a better release at both investigated pHs, with a faster and more complete release observed at pH 7.4.

yearjournalcountryeditionlanguage
2008-01-01
10.1016/j.ejps.2008.06.005http://hdl.handle.net/10447/39552