Search results for "Insulysin"

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DIFFERENTIAL SCANNING CALORIMETRY STUDY ON DRUG RELEASE FROM AN INULIN-BASED HYDROGEL AND ITS INTERACTION WITH A BIOMEMBRANE MODEL:pH AND LOADING EFF…

2008

Inulin has been derivatized with methacrylic anhydride (MA) and succinic anhydride (SA) to obtain a methacrylated/succinilated derivative (INU-MA-SA) able to produce a pH sensitive hydrogel after UV irradiation. The hydrogel was characterized and loaded with diflunisal (10.4, 17 and 24%, w/w) chosen as a model drug. The drug release from INU-MA-SA-based hydrogel to a biomembrane model made by unilamellar vesicles of dimyristoylphosphatidyl-choline (DMPC) was investigated at pH 4.0 and 7.4 by differential scanning calorimetry (DSC) that appears to be a suitable technique to follow the transfer kinetics of a drug from a controlled release system to a biomembrane model. The drug release from t…

Magnetic Resonance SpectroscopyINULIN HYDROGELS DRUG RELEASE DIFFERENTIAL SCANNING CALORIMETRYPharmaceutical ScienceDiflunisalMethacrylic anhydrideCentrifugationInsulysinDosage formchemistry.chemical_compoundDifferential scanning calorimetryX-Ray DiffractionSpectroscopy Fourier Transform InfraredmedicineHypoglycemic AgentsChromatography High Pressure LiquidChromatographyCalorimetry Differential ScanningVesicleAnti-Inflammatory Agents Non-Steroidaltechnology industry and agricultureSuccinic anhydrideInulinHydrogelsMembranes ArtificialSuccinatesHydrogen-Ion ConcentrationDiflunisalControlled releaseMolecular WeightchemistryChemical engineeringSolubilitySelf-healing hydrogelsSpectrophotometry UltravioletChromatography Thin LayerDimyristoylphosphatidylcholinemedicine.drug

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PEPhysical Sciences and Engineering
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LSLife Sciences
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SHSocial Sciences and Humanities
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