6533b832fe1ef96bd129aeed
RESEARCH PRODUCT
Total Synthesis of epi-Trichosetin.
Till OpatzUlrich KauhlLars Andernachsubject
Natural product010405 organic chemistryStereochemistryOrganic ChemistryTotal synthesis010402 general chemistry01 natural sciences0104 chemical sciencesTrichosetinchemistry.chemical_compoundchemistryYield (chemistry)Intramolecular forceProtecting groupdescription
The natural 3-decalinoyltetramic acid epi-trichosetin was synthesized in ten steps starting from ( R)-(+)-citronellal using an intramolecular Diels-Alder reaction and a Lacey-Dieckmann cyclization as the key steps. The use of a 2-nitrobenzyl protecting group resulted in an efficient synthetic endgame. The natural product was obtained in 4.1% overall yield.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-11-20 | The Journal of organic chemistry |