6533b832fe1ef96bd129af72
RESEARCH PRODUCT
Effects of calcium channel blockers on gastric emptying and acid secretion of the rat in vivo.
R. BrageEzequiel Marti-bonmatiJ EspluguesJulio CortijoC. RodriguezJuan V. Espluguessubject
Malemedicine.medical_specialtyGastric motilitychemistry.chemical_elementBlood PressureCalciumBiologyGastric AcidInternal medicinemedicineAnimalsAnesthesiaDiltiazemPylorusPharmacologyGastric emptyingDose-Response Relationship DrugCalcium channeldigestive oral and skin physiologyRats Inbred StrainsCalcium Channel BlockersRatsPentagastrinPerfusionEndocrinologychemistryGastric Emptyingcardiovascular systemGastric acidVerapamilFemalemedicine.drugResearch Articledescription
Abstract Experiments were designed to evaluate the effects of three calcium channel blockers (verapamil, diltiazem and cinnarizine) on gastric emptying and secretion in the rat. Pretreatment with the calcium blockers delayed gastric emptying of phenol red in a dose-dependent manner. Verapamil was the most effective of the agents tested. Verapamil and diltiazem inhibited gastric acid secretion in the pylorus-ligated rat without affecting pepsin output. Cinnarizine was ineffective in this model. When the perfused lumen of the anaesthetized rat was used, verapamil was found to inhibit responses to carbachol or histamine more than those to pentagastrin. Further, we found a greater sensitivity to verapamil for basal compared with vagal-stimulated (2-deoxy-D-glucose) acid secretion. Neither diltiazem nor cinnarizine modified gastric acid secretion in this experimental model. These findings are discussed in relation to the role of extracellular calcium in gastric motility and secretion, and the existence of a regional and functional selectivity for calcium blockers is proposed.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1986-12-01 | British journal of pharmacology |