6533b832fe1ef96bd129afb0

RESEARCH PRODUCT

Authors' response to: epithelial mesenchymal transition (EMT) in small airways of COPD patient.

Adela SerranoTeresa PeiróJulio CortijoJavier Milara Payá

subject

Pulmonary and Respiratory MedicineMalePathologymedicine.medical_specialtyEpithelial-Mesenchymal TransitionCopd patientsCOPD PathologyBronchiPulmonary Disease Chronic ObstructiveDownregulation and upregulationAirway EpitheliumSmokemedicineHumansEpithelial–mesenchymal transition1506COPDSmall airwaysbusiness.industrySmokingEpithelial CellsPostScriptmedicine.diseaseEpitheliumrespiratory tract diseasesmedicine.anatomical_structureRespiratory epitheliumImmunohistochemistryFemalebusiness

description

We understand the reservations highlighted by Sohal and Walters in their letter in response to our recent work published.1 In their letter, Sohal and Walters argue that E-cadherin and ZO-1 are absent in our immunohistochemistry analysis of small bronchi of smokers and COPD patients, and that if disappeared completely epithelium would fall apart.1 In our study, we detected downregulation of E-cadherin and ZO-1 as well as a change of intercellular and apical distribution to diffuse cytoplasmic redistribution (figure 3B; in our work published in Thorax on 7 January 2013),2 but not …

yearjournalcountryeditionlanguage
2013-07-12Thorax
10.1136/thoraxjnl-2013-203484https://pubmed.ncbi.nlm.nih.gov/23492370