6533b833fe1ef96bd129b65e

RESEARCH PRODUCT

Regulation of Acetylcholine Synthesis and Release in the Isolated Heart

W. WeideKonrad LöffelholzR. Lindmar

subject

Isolated Heart PreparationNerve stimulationResearch groupsVagal stimulationAcetylcholine synthesisChemistrymedicineIsolated heartPharmacologyAcetylcholinemedicine.drug

description

In the two decades following Loewi’s work (8,9) on the frog heart several research groups tried to use the isolated heart preparation from higher vertebrates for further investigations on synthesis, release and inactivation of acetylcholine (ACh). However the results were discouraging because the overflow of ACh during vagal stimulation was near, or below, the limit of the assay.

https://doi.org/10.1007/978-1-4684-8643-8_15