Automated synthesis and purification of [18F]fluoro-[di-deutero]methyl tosylate

6533b833fe1ef96bd129b6cd

RESEARCH PRODUCT

Automated synthesis and purification of [18F]fluoro-[di-deutero]methyl tosylate

S. Höhnemann Frank Rösch Friederike Beyerlein Markus Piel

subject

Methyl tosylate Organic Chemistry Total synthesis Biochemistry High-performance liquid chromatography Analytical Chemistry chemistry.chemical_compound chemistry Nucleophile Yield (chemistry)Drug Discovery Organic chemistry Radiology Nuclear Medicine and imaging Fluoride Spectroscopy

description

Automated synthetic procedures of [ 18 F]fluoro-[di-deutero]methyl tosylate on a GE TRACERlab FX F-N module and a non-commercial synthesis module have been developed. The syntheses included azeotropic drying of the [ 18 F]fluoride, nucleophilic 18 F-fluorination of bis(tosyloxy)-[di-deutero]methane, HPLC purification and subsequent formulation of the synthesized [ 18 F]fluoro-[di-deutero]methyl tosylate (d2-[ 18 F]FMT) in organic solvents. Automation shortened the total synthesis time to 50min, resulting in an average radiochemical yield of about 50% and high radiochemical purity (>98%). The possible application of this procedure to commercially available synthesis modules might be of significance for the production of deuterated 18 F-fluoromethylated imaging probes in the future. Copyright © 2013 John Wiley & Sons, Ltd.

year	journal	country	edition	language
2013-04-17	Journal of Labelled Compounds and Radiopharmaceuticals

https://doi.org/10.1002/jlcr.3043

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