6533b833fe1ef96bd129b72b

RESEARCH PRODUCT

HLA antigens and immunoresponsiveness to insulin in insulin-dependent diabetes mellitus.

J. BeyerH. DrostJörg BertramsF.a. GriesE. KuwertF.k. JansenD. GrunekleeH. E. Reis

subject

medicine.medical_specialtyHigh respondermedicine.medical_treatmentInsulin AntibodiesImmunologyHuman leukocyte antigenBiochemistryAntigenHLA AntigensDiabetes mellitusInternal medicineHistocompatibility AntigensGeneticsmedicineDiabetes MellitusImmunology and AllergyHumansInsulinbusiness.industryInsulinGeneral Medicinemedicine.diseaseEndocrinologyInsulin dependent diabetesImmunologyJuvenile diabetes mellitusbusinessJuvenile-onset diabetes mellitus

description

HLA-A and B antigens were determined in 112 patient with insulin-dependent juvenile onset diabetes mellitus, who could be subdivided into “non” and “high responders” to insulin. The data revealed a trend of an association of these diabetes subgroups with only one of the diabetes-associated antigens HLA-B8 and HLA-BW15 and indicated the existence of at least two different genetic constellations for susceptibility to juvenile diabetes mellitus. One form with a strong immune-response to insulin seemed to be associated with HLA-BW 15 and the other form without humoral immunoreactivity to insulin seemed to be associated with the presence of HLA-B8 and the absence of HLA-B7.

yearjournalcountryeditionlanguage
2008-12-11Tissue antigens
10.1111/j.1399-0039.1976.tb00546.xhttps://pubmed.ncbi.nlm.nih.gov/960073