Prestress in the extracellular matrix sensitizes latent TGF-β1 for activation

6533b833fe1ef96bd129b770

RESEARCH PRODUCT

Prestress in the extracellular matrix sensitizes latent TGF-β1 for activation

Boris Hinz Mercedes Costell Elisabeth Génot Franco Klingberg Thomas M. Quinn Stellar Boo Benjamin A. Alman Anne Koehler Melissa L. Chow Lara Buscemi

subject

Integrins Animals; Cell Differentiation; Cells Cultured; Extracellular Matrix/metabolism; HEK293 Cells; Humans; Integrins/metabolism; Integrins/physiology; Mechanotransduction Cellular; Myofibroblasts/cytology; Myofibroblasts/metabolism; Rats Wistar; Transforming Growth Factor beta1/metabolism medicine.medical_treatment Cellular differentiation Cèl·lules Integrin Context (language use)Biology Mechanotransduction Cellular Article Extracellular matrix Transforming Growth Factor beta1 Membranes (Biologia)medicine Animals Humans Rats Wistar Myofibroblasts Cells Cultured Research Articles Growth factor HEK 293 cells Cell Differentiation Cell Biology Extracellular Matrix HEK293 Cells biology.protein Biophysics Myofibroblast Transforming growth factor

description

A mild strain induced by matrix remodeling mechanically primes latent TGF-β1 for its subsequent activation and release in response to contractile forces.

year	journal	country	edition	language
2014-01-01

10.1083/jcb.201402006 http://hdl.handle.net/10550/54633

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