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RESEARCH PRODUCT
Expression of HIP/PAP mRNA in Human Hepatoma Cell Lines
Monica NotarbartoloM. CervelloGiuseppe MontaltoJuan L. IovannaLucrezia VirrusoNatale D'alessandroM. La RosaLydia Giannitrapanisubject
Pathologymedicine.medical_specialtyCarcinoma HepatocellularSettore MED/09 - Medicina InternaPancreatitis-Associated ProteinscarcinomaGeneral Biochemistry Genetics and Molecular BiologyHistory and Philosophy of ScienceAntigenAntigens NeoplasmHIP/PAPBiomarkers TumorTumor Cells CulturedmedicineCarcinomaHumansNeoplasmLectins C-TypeRNA MessengerPancreatitis-Associated ProteinsN-Glycosyl HydrolasesGenePlant ProteinsMessenger RNAbusiness.industryGeneral NeuroscienceLiver NeoplasmsAcute-phase proteinpancreatitihepatomamedicine.diseasePancreatitisHepatocellular carcinomaRibosome Inactivating Proteins Type 1Cancer researchproteinbusinessAcute-Phase Proteinsdescription
The present study attempts to shed more light on the role of hepatocarcinoma-intestine-pancreas/pancreatic associated protein (HIP/PAP) in hepatoma cells. We initially examined, by reverse transcription-polymerase chain reaction (RT-PCR), the HIP/PAP transcripts present in human hepatoma cell lines of different origins and with different grades of differentiation and genetic profiles. We also used DNA sequencing analysis to investigate the structure of the HIP/PAP gene. Further investigation is necessary to define the role of HIP/PAP during the development of human hepatocellular carcinoma and to ascertain whether the use of different transcripts is helpful in regulating HIP/PAP expression in transformed liver cells.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2002-07-04 | Annals of the New York Academy of Sciences |