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RESEARCH PRODUCT
How odorant metabolizing enzymes shape odor perception?
Jean-marie Heydelsubject
[SDV.AEN] Life Sciences [q-bio]/Food and Nutrition[SDV.BBM] Life Sciences [q-bio]/Biochemistry Molecular Biologyodorant metabolism[SDV.BBM]Life Sciences [q-bio]/Biochemistry Molecular Biologyperireceptorodorant metabolizing enzyme[SDV.AEN]Life Sciences [q-bio]/Food and Nutritionpsychological phenomena and processesolfactiondescription
International audience; Lingering in the background of every odorant-receptor interaction is an odor metabolizing enzyme. Over the last several years, a fascinating set of studies in rodents, rabbits, insects and humans has demonstrated that these enzymes participate in the active biotransformation of odorous molecules within the perireceptor environment. These mechanisms may exert two unique effects: first, to maintain odor sensitivity by reducing receptor saturation, and second, to transform the local milieu of the odor components giving rise to unique odor percepts. This symposium will focus on the impact of odorant metabolizing enzymes (OMEs) on functional and behavioral aspects of olfactory perceptual processing. Individual presentations will span in vitro, in vivo, and ex vivo models of odor enzymatic biotransformation, and will also span different model systems from insects to rodents to humans. Dr. Andrea Buettner will describe her food chemistry research illustrating the metabolic and perceptual consequences of ingested odors on the generation of new odor volatiles; Dr. Thomas Chertemps will present recent electrophysiological and molecular biology work involving effects of insect OMEs on the perception of pheromones and host odors; Dr. Hiro Matsunami will speak about his latest findings examining how OMEs modulate the activation of odorant receptors in vitro; and Dr. Aline Robert-Hazotte will discuss her newest findings linking effects of peripheral OME activity on human olfactory perception. This symposium will highlight cutting-edge work across different countries (USA, Germany, France) and different levels of training (1 postdoc scholar, 2 full professors, 1 assistant professor), and is evenly balanced across women and men. Together this set of talks will bring innovative and integrative understanding to the role and relevance of OME activity on chemosensory function.
year | journal | country | edition | language |
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2020-08-03 |