6533b833fe1ef96bd129c1e6
RESEARCH PRODUCT
Secondary Progression in Multiple Sclerosis: Neuronal Exhaustion or Distinct Pathology?
Alexandre PratCatherine LarochelleTimo UphausFrauke Zippsubject
0301 basic medicineSenescencePathologymedicine.medical_specialtyMultiple SclerosisDiseaseGrey matter03 medical and health sciences0302 clinical medicineAtrophymedicineHumansSecondary progressiveNeuronsbusiness.industryGeneral NeuroscienceMultiple sclerosisNeurodegenerationBrainmedicine.diseaseMagnetic Resonance Imaging030104 developmental biologymedicine.anatomical_structureDisease ProgressionbusinessNeuroscience030217 neurology & neurosurgeryProgressive diseasedescription
Prevention of progression in neurological diseases, particularly in multiple sclerosis (MS) but also in neurodegenerative diseases, remains a significant challenge. MS patients switch from a relapsing-remitting to a progressive disease course, but it is not understood why and how this conversion occurs and why some patients never experience disease progression. Do aging and accumulation of neuronal damage induce progression, or do cognitive symptoms and accelerated grey matter (GM) atrophy point to distinct processes affecting networks? This review weighs accepted dogma against real data on the secondary progressive phase of the disease, highlighting current challenges in this important field and directions towards development of treatment strategies to slow or prevent progression of disability.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2016-05-01 | Trends in Neurosciences |