6533b833fe1ef96bd129c220

RESEARCH PRODUCT

Human cytomegalovirus glycoprotein B genotypes in immunocompetent, immunocompromised, and congenitally infected Italian populations

S. De GraziaEmilio IannittoP. Di CarloGiovanni M. GiammancoSerenella Arista

subject

Human cytomegalovirusSettore MED/07 - Microbiologia E Microbiologia Clinicamedicine.medical_specialtyGenotypevirusesRestriction MappingCongenital cytomegalovirus infectionCytomegalovirusHIV Infectionsmedicine.disease_causePolymerase Chain ReactionHerpesviridaeVirusImmunocompromised HostMedical microbiologyViral Envelope ProteinsBetaherpesvirinaeVirologyGenotypemedicineHumansBone Marrow TransplantationbiologyInfant Newbornvirus diseasesGeneral Medicinebiology.organism_classificationmedicine.diseaseKidney TransplantationVirologyHuman cytomegalovirus immunocompromised gB genotypes ItalyCytomegalovirus InfectionsViral diseaseImmunocompetence

description

Human cytomegalovirus (HCMV) strains, obtained from immunocompetent and immunocompromised Italian hosts, were typed with glycoprotein B (gB) gene restriction analysis. A predominant circulation of HCMV strains with gB type 2 and 3 was detected in both the immunocompetent host with a primary HCMV infection and the immunocompromised host with or without HCMV disease. No association between gB types and subjects with different risks of developing HCMV disease was found. All four gB genotypes were capable of causing congenital infection in Italian babies, with gB type 1 accounting for 50% of the strains examined in symptomatic infants and a remarkable incidence of gB type 4 viruses.

yearjournalcountryeditionlanguage
2003-02-01Archives of Virology
https://doi.org/10.1007/s00705-002-0941-0