6533b833fe1ef96bd129c243

RESEARCH PRODUCT

A novel haemoprotein induced by isosafrole pretreatment in the rat

James W. BridgesClifford R. ElcombeK. J. NetterMaurice Dickins

subject

MaleHemeproteinCytochromeSodiumBiophysicschemistry.chemical_elementDioxolesBiochemistrychemistry.chemical_compoundCytochrome P-450 Enzyme SystemIsomerismSafroleMoleAnimalsMolecular BiologyGel electrophoresisChromatographybiologyChemistrySpectrum AnalysisCell BiologyRatsMolecular WeightBiochemistryIsosafroleEnzyme InductionPhenobarbitalMicrosomes Liverbiology.proteinApoproteinsMethylcholanthrene

description

Abstract Sodium dodecyl sulphate-polyacrylamide gel electrophoresis has been used to demonstrate that pretreatment of rats with isosafrole results in the formation of a novel species of cytochrome P-450 (mol. wt. 54,000) quite distinct from that induced by phenobarbitone pretreatment (mol. wt. 50,000) or 3-methylcholanthrene (mol. wt. 58,000).

yearjournalcountryeditionlanguage
1978-01-13Biochemical and Biophysical Research Communications
https://doi.org/10.1016/0006-291x(78)91108-7