0000000000416827

AUTHOR

Maurice Dickins

showing 2 related works from this author

SUBSTRATE-ELICITED DISSOCIATION OF THE ISOSAFROLE METABOLITE-CYTOCHROME P-450 COMPLEX AND THE CONSEQUENTIAL REACTIVATION OF MONOOXYGENATION

1977

ABSTRACT The present study was initiated to determine whether the substrate-elicited dissociation of the isosafrole metabolite-cytochrome P-450 complex resulted in increased monooxygenase activity. It was found that the substrates p -nitroanisole and ethoxycoumarin would elicit dissociation, furthermore this dissociation was accompanied by increased dealkylation of the substrates. Benzo(a)pyrene was found not to effect the dissociation of the complex, while biphenyl, which undergoes a similar hydroxylation, was effective.

BiphenylCytochromebiologyChemistryStereochemistryMetaboliteAlkylationhumanitiesDissociation (chemistry)Hydroxylationchemistry.chemical_compoundIsosafrolebiology.proteinPyrene
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A novel haemoprotein induced by isosafrole pretreatment in the rat

1978

Abstract Sodium dodecyl sulphate-polyacrylamide gel electrophoresis has been used to demonstrate that pretreatment of rats with isosafrole results in the formation of a novel species of cytochrome P-450 (mol. wt. 54,000) quite distinct from that induced by phenobarbitone pretreatment (mol. wt. 50,000) or 3-methylcholanthrene (mol. wt. 58,000).

MaleHemeproteinCytochromeSodiumBiophysicschemistry.chemical_elementDioxolesBiochemistrychemistry.chemical_compoundCytochrome P-450 Enzyme SystemIsomerismSafroleMoleAnimalsMolecular BiologyGel electrophoresisChromatographybiologyChemistrySpectrum AnalysisCell BiologyRatsMolecular WeightBiochemistryIsosafroleEnzyme InductionPhenobarbitalMicrosomes Liverbiology.proteinApoproteinsMethylcholanthreneBiochemical and Biophysical Research Communications
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